The burden of co-infection with human immunodeficiency virus type 1 and malaria in pregnant women in sub-saharan Africa.” Am J Trop Med Hyg 71(2 Suppl

Abstract. In sub-Saharan Africa, human immunodeficiency virus (HIV) and malaria are among the leading causes of morbidity during pregnancy. We reviewed available information collected since the first report 15 years ago that HIV impaired the ability of pregnant women to control malaria parasitemia. Results from 11 studies showed that HIV-infected women experienced consistently more peripheral and placental malaria (summary relative risk 1.58 and 1.66, respectively), higher parasite densities, and more febrile illnesses, severe anemia, and adverse birth outcomes than HIV-uninfected women, particularly in multigravidae. Thus, HIV alters the typical gravidity-specific pattern of malaria risk by shifting the burden from primarily primigravidae and secundigravidae to all pregnant women. The proportional increase of malaria during pregnancy attributable to HIV was estimated to be 5.5 % and 18.8 % for populations with HIV prevalences of 10 % and 40%, respectively. Maternal malaria was associated with a two-fold higher HIV-1 viral con-centrations. Three studies investigating whether placental malaria increased mother-to-child HIV-1 transmission showed conflicting results, possibly reflecting a complex balance between placental malarial immune responses and stimulation of HIV-1 viral replication. Further investigations of interactions between antiretroviral drugs, prophylaxis with cotri-moxazole, and antimalarial drugs in pregnant women are urgently needed. Although much has been learned in the pas